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KMID : 0931320090090010022
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대한상부위장관.헬리코박터학회지
2009 Volume.9 No. 1 p.22 ~ p.25
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Helicobacter pylori Infection and Gastric Cancer
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Kim Hyun-Soo
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Abstract
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Helicobacter pylori (H. pylori) infect a half of mankind and it is a Gram-negative bacterium etiologically involved in chronic atrophic gastritis, peptic ulcer disease, gastric cancer and gastric MALT lymphoma. H. pylori is designated as a definitive carcinogen by the WHO. Gastric cancer is the most common malignancy in Korea and is second reading cause of cancer related deaths each year. The progression to gastric cancer is a complex multi-step process involving complicated interaction between, environmental, bacterial and host factors. There is little doubt that H. pylori infection is a major risk factor in the pathogenesis of distal gastric cancer. Chronic H. pylori infection in stomach is also known to affect proliferation and cellular transformation. H. pylori infection is associated with the induction of chronic inflammation in gastric mucosa and with the progressive development of metaplastic change, and this metaplstic change of stomach precedes the development of most gastric adenocarcinoma. So we discuss the role of H. pylori in gatric carcinogenesis.
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KEYWORD
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Helicobacter pylori, Gastric cancer
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